Have you ever read a manuscript that was too "twisted"?
No. I reject those at the query stage. I'm not the right agent for graphic violence or sadistic cruelty. I've received queries that I've literally stopped reading after one sentence to send a very quick, very terse "not for me" reply.
If your book has elements that are disturbing, you'll do well to soft pedal them in the query. The query is too short to lead a reader into anything brutal. It's like being doused with a bucket of ice water and we've all see what that's like
You can lead a reader into things that are pretty graphic if you've got time and page count on your side. I've ended up reading books that were definitely more "twisted" than I'd have said I was ok with but by the time I got to those scenes, they were part of a plot that made sense.
The most recent example I can think of is in I AM PILGRIM by Terry Hayes. He's got a scene in that book that was absolutely essential to the plot but ohmygodiva...ICK.
This is another example of why it's important to query widely and not set your heart on some "dream agent." You have no way to know what is "too" anything for any agent.