I try to read the books shortlisted for major crime prizes: Edgars, Malice, ThrillerFest etc.
Sometimes it takes me a while to read them all but I really like to see what caught reader's attention, and think about what those books mean for acquisitions in the future.
Recently I started one such book.
I read about 23 pages and put it down.
There's nothing wrong with the book. It's well written. It's shortlisted for a good prize.
But the story held absolutely no interest for me.
Given the scarcity of my reading time, I elected to not finish the book.
This happens in the incoming queries as well.
Sometimes you've written a book I don't want to read.
There's nothing wrong with you.
There's nothing wrong with me (ok, never mind that)
There's nothing wrong with your book.
Fretting about how to revise to garner my interest is NOT what you want to spend your time on.
You want to spend your time querying widely.
No list of "what I'm looking for" or MSWL will prevent you from querying agents who just don't connect with your book.
Pinning your hopes on some dream agent ignores the very real possibility that your tastes are not sympatico.
These are rejections you cannot avoid even with the spiffiest of queries and the most compelling book.