There are just a few things that are automatic passes at the query stage.
1. Fiction novel
This is the big one. All novels are fiction, and since words are the tools of your craft, when you abuse them, I know you're not the kind of master craftsman I want to hire to decorate my bank account.
2. Unfinished novel
I can sell unfinished novels. I've done it. But that novel didn't arrive in the incoming queries; it was from an established client.
When you're querying for representation, your novel must be finished. I pass on everything that isn't.
3. The novel has been previously published.
Some agents take on previously published work. I don't.
There are a couple other things that aren't quite auto-pass but pretty darn close.
4. "Tell me why I should hire you?" leads the list.
I'm not going to pitch you on the value of an agent for your work, or why I'm the best choice for you unless I've read your work and want to take it on. If you don't understand the value of an agent, or don't want an agent, or think agents are slime creatures, that's fine. Don't query me. I'm totally ok with that.
5. No query letter, just pages.
I'll give those queries a very VERY quick skim but someone who doesn't include a query isn't telling me what I need to know to evaluate the project. I'm passing on those cause frankly life is too short to provide Remedial Querying one to one. And there's this thing called QueryShark...
I'll give you a pass on lie/lay/lay since dollars to doughnuts, at least 25% of y'all get it wrong. But homonyms, those I don't forgive so easily. As in #1, words are the tools of your trade and if you don't know wave/waive or shudder/shutter that's just sloppy proof reading. It's not bad that you make the mistake, it's bad that you didn't see it and fix it when you revised your query.
7. Typing your email query in all caps
I respond to these emails with the same form letter I use with all other passes.
It's up to you to re-read your query and make sure none of these things are there.