Is it possible that the query or manuscript reviewer wouldn't even get past the title if they didn't like it? How important is the author's proposed title?
I've seen titles that were instant turn-offs. Of course I'm hardpressed to think of them now, but they were things like "Bedbugs and Bad Children"--so horrible they overshadowed everything to come.
Generally though, bad titles are a fact of life at the query stage. At the submission stage too if you were to poll editors I work with. More than once I've pitched a title only to hear a strangled yelp on the other end and quickly added "of course, you'll want to change that title."
Fabulous client Jeff Somers and I joke that he comes up with the worst titles in the world for his manuscripts, and when he recites a couple of examples to his boon companions at the bar, they collapse with laughter and agree. I've sold eight books for Jeff and almost none of them have the same title they started with. Didn't dissaude me from reading any of his manuscripts.
I think if you avoid bedbugs, incest and abuse references in a title you'll be ok.