Does this story surprise me and take me to places I didn’t expect?
Is this a main character I care about?
Am I personally moved by this story or situation?
Has this been done a million times before?
Is the voice/character authentic and real?
We can fix a lot of things (grammar, syntax and structure) but we can't fix these. These have to be right before we say yes.
I found this on Kathy Temean's very useful blog.