Kristin Nelson hits it on the nose.
Not only do informed writers write better queries, they're knowledgeable about how to act.
I've received only one irate letter from a person I met at a conference. I've gotten dozens of others over the years from people who just cold queried me. (Interestingly it's dropped off dramatically now that I don't offer any helpful suggestions to anyone!)
I don't think I can extrapolate that informed writers don't want to strangle me sometimes (heck, I'm lucky my clients are only homicidal on paper!) but I can conclude that writers who've taken the time to learn about the industry know it's not in their best interest to do so.
What was the your starting point? You wrote -The End- and then what did you do?